Journal article
Response and Resistance to Menin Inhibitor in UBTF–Tandem Duplication AML
IS Tiong, DS Ritchie, P Blombery
New England Journal of Medicine | MASSACHUSETTS MEDICAL SOC | Published : 2024
DOI: 10.1056/NEJMc2404110
Abstract
Tandem duplication in UBTF is associated with a resistant form of AML. A menin inhibitor induced a short-lived response. Resistance was associated with mutations at the drug-binding site in MEN1, w...
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Grants
Awarded by Snowdome Foundation
Funding Acknowledgements
Supported by the Snowdome Foundation, the Wilson Centre for Blood Cancer Genomics, and a Synergy grant (GNT2011139 to Dr. Blombery) from the Australian National Health and Medical Research Council.